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pentobarbital will decrease the extent or effect of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Powerful CYP3A4 inducers may perhaps reduce suvorexant efficacy; if amplified suvorexant dose needed, do not exceed twenty mg/daypentobarbital will reduce the extent or effect of elbasvir/grazoprevir by impac